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With the cellular and topographic distribution of sulfatide storage throughout the cns of asa(-/-) mice between a few days and 24 months of age. generic viagra no rx
Sulfatide accumulation was detected on the ultrastructural level and by histochemical staining with alcian blue.
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Sulfatide storage was found in oligodendroglia and neurons in young mice, and in activated microglia (phagocytes) in adult mice. pills just like viagra
Neuronal sulfatide storage was most prominent in many nuclei of the medulla oblongata and pons, and in several nuclei of midbrain and forebrain. viagra soft wiki Sulfatide-storing phagocytes were most frequent in the white matter tracts of aged asa(-/-) mice, whereas no widespread demyelination was obvious.
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Loss of neurons was found in two nuclei of the auditory pathway of aged asa(-/-) mice (ventral cochlear nucleus and nucleus of trapezoid body). reviews on generic viagra The distributional pattern of sulfatide storage throughout the cns of asa(-/-) mice largely corresponds to data reported for human mld.
An important difference, however, which remains unexplained at present, is the absence of obvious demyelination from the cns of asa(-/-) mice up to the age of 2 years.
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Histochem cell biol.
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2001 aug ;116 (2):161-9 11685544 cit:12 lysosomal sulfoglycolipid storage in the kidneys of mice deficient for arylsulfatase a (asa) and of double-knockout mice deficient for asa and galactosylceramide synthase. bayer viagra 20mg [my paper] r lã¼llmann-rauch , u matzner , s franken , d hartmann , v gieselmann department of anatomy, university of kiel, olshausenstrasse 40, 24098 kiel, germany. bayer viagra 20mg R.
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De the inherited deficiency of arylsulfatase a (asa) causes lysosomal accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, s-galcer ) and leads to metachromatic leukodystrophy in humans. viagra office canada Among visceral organs, kidneys are particularly affected. does viagra oral jelly work In the present study, the regional distribution and temporal development of sulfoglycolipid storage in kidneys of asa-/- mice was investigated histochemically (alcian blue) and ultrastructurally.
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Furthermore, the sulfoglycolipid storage was examined in kidneys of double-knockout mice, which are incapable of:(a) degrading any sulfolipids (asa-/-) and (b) synthesizing the major sulfolipid s-galcer because of deficiency for galactosylc. bayer viagra 20mg
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